In the first decade of the sixteenth century the work of Raphael indicates a strong interest in episodes on the flight of the Holy Family into Egypt. During his Florentine period (1504-1508) Raphael did at least two versions of the legendary Riposo or Rest on the Flight into Egypt.
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Franciscan friar and mathematician Luca Pacioli wrote several books on mathematics and geometry. Among them, in 1497, Pacioli conceived De Divina Proportione, a treatise in vulgar on mathematical proportions applied to geometry and art with a specific focus on architecture and the human figure. The work was finally published in 1509 featuring illustrations by Leonardo da Vinci.